Efficient Synthesis of Macromolecular DO3A@Gn Derivatives for Potential Application in MRI Diagnostics: From Polymer Conjugates to Polymer Nanoparticles

Abstract Herein, the synthesis of three different macromolecular DO3A@Gn conjugates based on poly(2‐oxazoline)s is presented. Therefore, poly(2‐methyl‐2‐oxazoline) synthesized by a ring‐opening, cationic polymerization and terminated with DO3A( t Bu) 3 . The best results are obtained after 48 h at 120 °C degree termination 86%. After deprotection DO3A ligand complexation Gn 3+ , relaxivity as measured magnetic field strength 9.4 T (400 MHz) reveals values for r 1 up to 2.32 m −1 s concept extended block copolymer 2‐heptyl‐2‐oxazoline 2‐methyl‐2‐oxazoline that again form micelles size 12.6 ± 0.7 nm 1,4,7,10‐tetraazacyclododecane‐ N ‐tetraacetic acid ligand. 10.1 determined from slope plot 1/T against gadolinium(III) concentration T. Finally, crosslinked nanoparticles prepared amphiphilic macro‐monomers in water throughout core presence azoisobutyronitrile (AIBN). nanoparticle 32.9 7.8 6.77